References:
#1 cause of cancer-related death (Jemal, et al, CA Cancer J Clin 2007; 57:43-66).
Estimates in U.S.: >226,000 new cases of lung cancer, >160,000 deaths (American Cancer Society, 2012).
Tobacco use accounts for 80% of lung cancer deaths and at least 30% of all cancer deaths (Cancer Facts & Figures 2012).
Nearly 500,000 bronchoscopies are performed annually in the U.S. to diagnose lung disease and lung cancer (Ernst et al. CHEST 2003;123(5): 1693-1717)
More than 150,000 patients per year in the U.S. present their physicians with the diagnostic dilemma of a Solitary Pulmonary Nodule (SPN) (Swensen SJ, et al. Mayo Clin Proc 1999; 74:319-29)
Higher rate detection of lung nodule in CT-scans (13% prevalence in ELCAP) , Henscke, C, et al. NEJM 2006; 355:1763-71
Results of initial low-dose computed tomographic screening for lung cancer. National Lung Screening Trial Research Team, Church TR, Black WC, Aberle DR, Berg CD, Clingan KL, Duan F, Fagerstrom RM, Gareen IF, Gierada DS, Jones GC, Mahon I, Marcus PM, Sicks JD, Jain A, Baum S. N Engl J Med. 2013 May 23;368(21):1980-91. doi: 10.1056/NEJM.
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